March Madness 2018 Lines: Sweet 16 Point Spreads, Complete Betting Odds

Three-quarters of the NCAA Tournament teams have been eliminated from national championship contention, and no one could have predicted this remaining field. Two No.1 seeds failed to reach the Sweet 16 in March Madness 2018, and more than half of the top four seeds were upset in the first two rounds.

No.1 Kansas and No.1 Villanova are still alive, as are No.2 Purdue and No.2 Duke. The Blue Devils are by far the biggest betting favorites in the Sweet 16, according to the latest betting odds.

The contest between Duke and No.11 Syracuse is the only Sweet 16 game with a betting line in double-digits. The Orange needed three wins to survive the first week, including victories over No.6 TCU and No.3 Michigan State, though it was just a few weeks ago that they lost by 16 points to Duke in ACC play.

No.5 Kentucky is the second-biggest favorite in the Sweet 16. They’ll face No.9 Kansas State after getting wins over a No.12 and a No.13 seed. A win for the Wildcats would give them a matchup with either a No.11 or a No.7 seed with a trip to the Final Four on the line.

No team is favored to defeat a higher seeded team and reach the Elite Eight. No.7 Loyola-Chicago is the closest in their matchup with No.7 Nevada. They are just two-point underdogs Thursday night.

Neither Kansas nor Villanova is favored by more than five points Friday night. The matchup between No.3 Texas Tech and No.2 Purdue features the upcoming round’s smallest point spread.

Duke Basketball Duke is the biggest betting favorite in the 2018 Sweet 16. Pictured: PITTSBURGH, PA – MARCH 17: Grayson Allen #3 of the Duke Blue Devils celebrates from the bench against the Rhode Island Rams during the second half in the second round of the 2018 NCAA Men’s Basketball Tournament at PPG PAINTS Arena on March 17, 2018 in Pittsburgh. Photo: Rob Carr/Getty Images

Below are the available betting lines for Thursday’s and Friday’s Sweet 16 games, via OddsShark.


No.11 Loyola-Chicago (+2) vs. No.7 Nevada, 143

No.7 Texas A&M (+3) vs. No.3 Michigan, 134

No.9 Kansas State (+6) vs. No.5 Kentucky, 138.5

No.9 Florida State (+5.5) vs. No.4 Gonzaga, 153


No.5 Clemson (+4) vs. No.1 Kansas, 143

No.5 West Virginia (+5) vs. No.1 Villanova, 152.5

No.11 Syracuse (+11) vs. No.2 Duke, 133.5

No.3 Texas Tech (+1.5) vs. No.2 Purdue, 137.5

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